nhaK [2017-06-06 14:04:54]

cation/H antiporter

locus: BSU33420

pI: 9.22

mw: 75.05 kDa

protein length: 670 aa

gene length: 2010 bp

function: monovalent cation export

product: cation/H antiporter

essential: no

synonyms: yvgP

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,428,331 → 3,430,343

The protein

Catalyzed reaction/ biological activity

• export of Na(+), K(+), Li(+), Rb(+)

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|17F0D94ED61E0AF1015FBC845BC2B5B670311C6F|nhaK]
  description: [Pubmed|16021482]

  regulation

  • constitutive, expression increases in the presence of Na⁺ and K⁺ [Pubmed|16021482]

Biological materials

Mutant

• MGNA-A455 (yvgP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/455 NBRP B. subtilis, Japan]
• GP2226 (''[gene|17F0D94ED61E0AF1015FBC845BC2B5B670311C6F|nhaK]''::''aphA3''), available in [SW|Jörg Stülke]'s lab [pubmed|28420751]

References

Reviews

• 27935846

Original publications

• 16021482,28420751